当归促进短期雷帕霉素诱导的急性胸腺退化小鼠胸腺皮质再生

Description

Xu and colleagues test a traditional Chinese herb on immune ageing in mice. Their 2026 paper asks whether Angelica sinensis, known as danggui, can help the thymus regrow after damage from rapamycin, a drug that shrinks this T-cell training organ. Seventy-eight female mice received rapamycin to trigger acute thymic decline, then varying doses of the herb during recovery.

Rapamycin shrank the thymus, weakened grip strength, and disrupted the cortex, the region where T cells mature. Medium and high herb doses enlarged the cortical area in a dose-dependent way and repaired the support-cell network inside it. Treated mice also matured their T cells more evenly and restored normal cell positioning. The herb raised activity in the Wnt signalling route and its downstream partner Foxn1, which the authors credit for the regrowth.

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Source: https://europepmc.org/article/MED/PMC13598562