On Serine Octamer Substitution Reactions
Brison A Shira, Alana K E Thomas, R Graham Cooks · 2026
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Description
Brison A Shira, Alana K E Thomas, and R Graham Cooks study a curious cluster of the amino acid serine. Eight serine units can lock together into a charged cluster that strongly favors partners of the same handedness, left or right. Such clusters interest chemists who probe how life's molecules came to favor one handedness over the other.
Using an ion trap mass spectrometer, the team swapped single amino acids into the cluster and watched which swaps it accepted. Swaps kept the same-handed preference in most cases, though two swaps at once, or swaps with less common amino acid forms, weakened or even flipped that preference. Their reading is that the cluster forms first, then trades units one at a time, guided by weak forces that can sense handedness.
Catalog record
| CREATOR | Brison A Shira, Alana K E Thomas, R Graham Cooks |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 21 KB |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |