类端粒沉默干扰体1通过p38 MAPK/线粒体动力学稳态轴调控神经元淀粉样前体蛋白表达
玉珉 张, 飞宇 朱, 啸天 吴, 占松 李, 鹏 黄, 延盼 高, 玲晖 曾 · 2026
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Description
Zhang Yumin and co-authors study a gene silencing regulator in Alzheimer's disease models in a 2026 paper. The regulator tags gene packing and may drive how much of a key precursor protein nerve cells make, the protein whose parts clump in the illness.
Mouse and cell models of the illness anchor the work. A drug that blocks the regulator was tested alone and with a booster of a stress signal path. Blots and gene reads track cell power plant splits and merges, protein cleanup marks, and levels of the precursor and its cutting enzymes. Data mining of protein webs hunts the paths at play.
Catalog record
| CREATOR | 玉珉 张, 飞宇 朱, 啸天 吴, 占松 李, 鹏 黄, 延盼 高, 玲晖 曾 |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 31 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |