Protocol to interrogate the role of creeping fat and mechanical tension in Crohn’s disease using a surgical mouse model of intestinal fibrosis
Elijah J. Suh, Benjamin Pham, Khristian E. Bauer-Rowe, Alexia Kim, Norah E. Liang, Joseph Y. Park, Deshka S. Foster, Jeffrey A. Norton, Daniel Delitto, Michael T. Longaker, Jeong S. Hyun · 2026
Read Protocol to interrogate the role of creeping fat and mechanical tension in Crohn’s disease using a surgical mouse model of intestinal fibrosis by Elijah J. Suh, Benjamin Pham, Khristian E. Bauer-Rowe, Alexia Kim, Norah E. Liang, Joseph Y. Park, Deshka S. Foster, Jeffrey A. Norton, Daniel Delitto, Michael T. Longaker, Jeong S. Hyun (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13266009.txt.
Description
Elijah J Suh and colleagues present a surgical mouse protocol for studying creeping fat and tension in Crohn's disease, published in 2026. Creeping fat wraps inflamed bowel and may drive strictures. Chemical colitis models cannot reproduce this mechanically driven scarring. A surgical model fills that gap.
Steps cover preparation, microsurgery to create a stricture under tension, and graft variations. Harvest, embedding, and sectioning procedures follow. The model produces local creeping fat and scarring through the bowel wall. Mice aged eight to twelve weeks are used. The protocol supports direct tests of how fat and tension interact.
Catalog record
| CREATOR | Elijah J. Suh, Benjamin Pham, Khristian E. Bauer-Rowe, Alexia Kim, Norah E. Liang, Joseph Y. Park, Deshka S. Foster, Jeffrey A. Norton, Daniel Delitto, Michael T. Longaker, Jeong S. Hyun |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 47 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |