Multifunctional scaffold based on Ti3C2Tx/PCL nanofibers composite hydrogel directs myogenic differentiation and microenvironment remodeling for volumetric muscle loss
Yihui Zhang, Wenkai Zhang, Zeyuan Xie, Wei Yu, Xiangqi Zhang, Yangwen Luo, Muge Gu, Jiayu Wang, Wei-En Yuan, Yebin Qian · 2026
Read Multifunctional scaffold based on Ti3C2Tx/PCL nanofibers composite hydrogel directs myogenic differentiation and microenvironment remodeling for volumetric muscle loss by Yihui Zhang, Wenkai Zhang, Zeyuan Xie, Wei Yu, Xiangqi Zhang, Yangwen Luo, Muge Gu, Jiayu Wang, Wei-En Yuan, Yebin Qian (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13194544.txt.
Description
Yihui Zhang and co-authors build a layered scaffold to help regrow muscle lost to severe injury. Their 2026 paper tackles volumetric muscle loss, where big chunks of muscle are gone. Healing stalls when new muscle cells fail to form and swelling lingers in the wound.
The scaffold stacks fiber sheets that hold a sheet-like mineral with gel layers that self-join. The mineral is wrapped in fibers to keep it from breaking down in water and losing its effect. In lab tests, cells stuck well to the scaffold and formed muscle far more strongly. Key muscle genes rose more than threefold. Early results point to a scaffold that both calms the wound and guides new muscle growth.
Catalog record
| CREATOR | Yihui Zhang, Wenkai Zhang, Zeyuan Xie, Wei Yu, Xiangqi Zhang, Yangwen Luo, Muge Gu, Jiayu Wang, Wei-En Yuan, Yebin Qian |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 62 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |