Sensitive protein alignments at tree-of-life scale using DIAMOND
Benjamin Buchfink, Klaus Reuter, Hajk-Georg Drost · 2021
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Description
Benjamin Buchfink, Klaus Reuter, and Hajk-Georg Drost presented in 2021 a greatly improved version of DIAMOND, a tool for aligning protein sequences very quickly. Biology is entering an age when the genomes of all known species may be sequenced, and comparing a new sequence against millions of known ones is a daily need. Older alignment tools are accurate but slow at that scale.
The improved DIAMOND keeps high sensitivity, catching distant matches that faster tools miss, while running at a pace suited to tree of life scale data. The authors benchmark it against alternatives on large collections. For comparative genomics, a tool that is both fast and sensitive decides which questions are even practical to ask.
Catalog record
| CREATOR | Benjamin Buchfink, Klaus Reuter, Hajk-Georg Drost |
|---|---|
| YEAR | 2021 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 43 KB |
| LICENSE | Creative Commons Attribution License |
| RIGHTS | CC BY |
| SOURCE | PubMed Central |