The role of m6A modification in the biological functions and diseases
Jiang X, Liu B, Nie Z et al. · 2021
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Description
Xiuling Jiang and co-authors reviewed in 2021 the roles of m6A, the most common internal chemical mark found on RNA in higher organisms. This small modification is added to RNA as it is made, and it is widespread and ancient in evolutionary terms. A set of proteins nicknamed writers places the mark, while other proteins read it and change what happens to the RNA.
The review explains how this marking system affects the life of RNA molecules, from their processing to their breakdown. It then connects the system to health, surveying diseases in which the marking machinery goes wrong. Because the marks can be adjusted, they have become an attractive target for new kinds of medicine.
Catalog record
| CREATOR | Jiang X, Liu B, Nie Z et al. |
|---|---|
| YEAR | 2021 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 62 KB |
| LICENSE | Creative Commons Attribution License |
| RIGHTS | CC BY |
| SOURCE | PubMed Central |