Impaired type I interferon activity and inflammatory responses in severe COVID-19 patients
Hadjadj J, Yatim N, Barnabei L et al. · 2020
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Description
Jérémie Hadjadj and colleagues reported in 2020 that patients with severe COVID-19 share a telling immune weakness. Interferons are the body's first alarm proteins against viruses, and type I interferons switch on a battery of antiviral genes. In these severely ill patients, that alarm was unusually faint, while inflammation elsewhere in the body ran high.
The team measured interferon activity and inflammatory signals in patients across levels of illness severity. The pairing they found, weak antiviral defense beside strong inflammation, helps explain why the virus can gain ground while the body's response still damages tissue. Their report pointed toward treatments that might restore the early alarm or calm the late inflammation, and it shaped how doctors thought about timing immune therapies.
Catalog record
| CREATOR | Hadjadj J, Yatim N, Barnabei L et al. |
|---|---|
| YEAR | 2020 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 5 KB |
| LICENSE | Creative Commons Attribution License |
| RIGHTS | CC BY |
| SOURCE | PubMed Central |