SARS-CoV-2 Receptor ACE2 Is an Interferon-Stimulated Gene in Human Airway Epithelial Cells and Is Detected in Specific Cell Subsets across Tissues
Ziegler CGK, Allon SJ, Nyquist SK et al. · 2020
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Description
Carly Ziegler and colleagues examined in 2020 how the virus that causes COVID-19 gets its first foothold in the human body. The virus uses a protein called ACE2 as its doorway into cells, helped by host enzymes that prime its spike protein. The team asked where in the body this doorway sits, and whether the body's own alarm signals change how much of it is made.
Using gene activity data from airway cells and tissues, they report that the gene for this doorway switches on more strongly after interferon, one of the body's virus alarm signals. They also pinpoint the exact cell types that carry it in the nose and elsewhere. That finding raised an important caution about how alarm signals might, in some settings, widen the virus's entry points.
Catalog record
| CREATOR | Ziegler CGK, Allon SJ, Nyquist SK et al. |
|---|---|
| YEAR | 2020 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 140 KB |
| LICENSE | Creative Commons Attribution License |
| RIGHTS | CC BY |
| SOURCE | PubMed Central |