PRSice-2: Polygenic Risk Score software for biobank-scale data
Choi SW, O'Reilly PF. · 2019
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Description
Seunggeun Choi and Paul O'Reilly presented PRSice-2, software for polygenic risk scores, in 2019. A polygenic score sums many tiny genetic effects into one risk number. Such scores now serve research on shared causes and causal tests.
PRSice-2 is built for the biobank era, handling hundreds of thousands of people quickly. It automates threshold tuning, where scores are built at many cutoffs and the best is kept. Careful handling of related variants reduces double counting. Genetics teams adopted it as a standard workhorse for score building and testing. The software is freely available and runs on ordinary desktop machines as well as clusters.
Catalog record
| CREATOR | Choi SW, O'Reilly PF. |
|---|---|
| YEAR | 2019 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 24 KB |
| LICENSE | Creative Commons Attribution License |
| RIGHTS | CC BY |
| SOURCE | PubMed Central |