Transcriptional Regulation by Nrf2
Tonelli C, Chio IIC, Tuveson DA. · 2018
Read Transcriptional Regulation by Nrf2 by Tonelli C, Chio IIC, Tuveson DA. (2018) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-6208165.txt.
Description
Claudia Tonelli, Iok Chio, and David Tuveson reviewed gene control by the Nrf2 pathway in 2018. Nrf2 is a protein that turns on a broad set of protective genes. Those genes defend cells against toxic and oxidative stress.
The review explains how Nrf2 is held in check in quiet times and freed when stress hits. It maps the genes switched on downstream and the diseases touched by the pathway. Cancer adds a twist, since tumors can hijack this defense to survive treatment. Understanding that balance is key to drugs that raise or block the pathway safely.
Catalog record
| CREATOR | Tonelli C, Chio IIC, Tuveson DA. |
|---|---|
| YEAR | 2018 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 56 KB |
| LICENSE | Creative Commons Attribution License |
| RIGHTS | CC BY |
| SOURCE | PubMed Central |