Multi-omics approaches to disease
Hasin Y, Seldin M, Lusis A. · 2017
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Description
Hasin, Seldin, and Lusis reviewed multi-omics approaches to disease in 2017. High-throughput technologies had revolutionized medical research in a short span of years. Gene chip arrays made genome-wide association studies possible at scale. Tools that read transcript levels across the genome then gave rise to integrative genetics.
Other omics technologies followed, covering proteins, metabolites, and more. Multi-omics combines these layers to see a disease process whole, rather than one molecule type at a time. A gene variant may matter only through the protein and pathway changes it causes. Layered data can reveal those chains and point to drug targets. The review maps how to join the layers without drowning in data.
Catalog record
| CREATOR | Hasin Y, Seldin M, Lusis A. |
|---|---|
| YEAR | 2017 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 57 KB |
| LICENSE | Creative Commons Attribution License |
| RIGHTS | CC BY |
| SOURCE | PubMed Central |