The amyloid hypothesis of Alzheimer's disease at 25 years
Dennis J Selkoe, John Hardy · 2016
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Description
Selkoe and Hardy revisited the amyloid hypothesis of Alzheimer's disease in 2016, twenty-five years on. The hypothesis holds that disease starts when the brain makes amyloid beta faster than it can clear it away. Debate about it has continued for decades.
The authors argue that new lines of evidence from labs and clinics worldwide support the concept. They present amyloid build-up as a very early, often initiating factor in Alzheimer's. That view guides drug development aimed at clearing or blocking amyloid early. The review is a key statement in the long argument over what causes this common dementia.
Catalog record
| CREATOR | Dennis J Selkoe, John Hardy |
|---|---|
| YEAR | 2016 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 92 KB |
| LICENSE | Creative Commons Attribution License |
| RIGHTS | CC BY |
| SOURCE | PubMed Central |