Infernal 1.1: 100-fold faster RNA homology searches
Eric P. Nawrocki, Sean R. Eddy · 2013
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Description
Nawrocki and Eddy present Infernal 1.1, a far faster version of their RNA homology search software. Infernal builds probabilistic profiles, called covariance models, of an RNA family's sequence and secondary structure. The input is a structurally annotated alignment of known family members.
The software then uses those models to search sequence databases for new members of the family. Version 1.1 runs about a hundred times faster than before, the authors report. Speed made structure-aware RNA search practical across whole genomes, supporting the Rfam database and RNA gene discovery. Faster searches also cut the energy cost of annotating huge sequence archives substantially.
Catalog record
| CREATOR | Eric P. Nawrocki, Sean R. Eddy |
|---|---|
| YEAR | 2013 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 12 KB |
| LICENSE | Creative Commons Attribution License |
| RIGHTS | CC BY |
| SOURCE | PubMed Central |