Acetylcholinesterase Inhibitors: Pharmacology and Toxicology
Colović MB, Krstić DZ, Lazarević-Pašti TD et al. · 2013
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Description
Colović, Krstić, Lazarevic-Pasti, and co-authors review acetylcholinesterase inhibitors, covering pharmacology and toxicology. The enzyme acetylcholinesterase ends nerve impulses by rapidly breaking down the messenger acetylcholine. It acts along cholinergic pathways throughout the central and peripheral nervous systems.
When inhibitors inactivate the enzyme, acetylcholine builds up, with effects that range from therapeutic to lethal. The review spans drugs that exploit this action and poisons, such as some pesticides and nerve agents, that abuse it. Understanding both sides guides safer medicines and better antidotes. Poisoning treatment also depends on the same enzyme science the review explains.
Catalog record
| CREATOR | Colović MB, Krstić DZ, Lazarević-Pašti TD et al. |
|---|---|
| YEAR | 2013 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 56 KB |
| LICENSE | Creative Commons Attribution License |
| RIGHTS | CC BY |
| SOURCE | PubMed Central |