Automated eukaryotic gene structure annotation using EVidenceModeler and the Program to Assemble Spliced Alignments
Brian J Haas, Steven L Salzberg, Wei Zhu et al. · 2008
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Description
Haas, Salzberg, Zhu, and co-authors describe automated tools for annotating gene structure in organisms with nuclei. Their EVidenceModeler program predicts where protein-coding parts of genes lie. A companion program assembles aligned pieces of RNA evidence into full gene models.
Together, the tools weigh several kinds of evidence at once, including alternate spliced forms and untranslated regions at gene ends. Automation matters because hand annotation cannot keep pace with new genomes. Consistent computer annotation gives researchers a reliable first map of a genome's genes to test and refine. Gene models from the pipeline feed directly into public genome databases.
Catalog record
| CREATOR | Brian J Haas, Steven L Salzberg, Wei Zhu et al. |
|---|---|
| YEAR | 2008 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 81 KB |
| LICENSE | Creative Commons Attribution License |
| RIGHTS | CC BY |
| SOURCE | PubMed Central |