An integrated view of metabolic and physiological regulation of toxin production in Clostridioides difficile
Chetna Dureja, Ann M. McKelvey, Julian G. Hurdle · 2026
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Description
Chetna Dureja and colleagues review what tells a gut germ to make its toxins, in this minireview from twenty twenty-six. The germ is Clostridioides difficile, a leading cause of diarrhea after antibiotics. Its two toxins do the damage, and the old picture said a control strip of DNA, tuned by nutrient signals, switches them on.
Newer work widens that picture a lot. The cell's fuel levels, metal stores, redox balance, and purine supply all feed into the toxin decision. So does the cell's choice between growing, sporulating, and attacking, and cells in one colony do not all decide alike. Strikingly, some small molecules can shut toxin output down without killing the germ. The authors argue this opens a kinder drug strategy: disarm the germ rather than blast it, sparing the gut's helpful microbes. Mapping the control web is the next step.
Catalog record
| CREATOR | Chetna Dureja, Ann M. McKelvey, Julian G. Hurdle |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 48 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |