Phage-first treatment results in subpopulation-driven collateral sensitivity to beta-lactams in an extensively drug-resistant Pseudomonas aeruginosa
Claire Han, Karishma Patel, Haoran Gao, Jacob T. Sanborn, Thomas D. Nguyen, Jack F. Klem, Brian M. Ho, Patrick D. Kenney, Yanan Zhao, Troy D. Wood, Dwayne R. Roach, Liang Chen, Nicholas M. Smith · 2026
Read Phage-first treatment results in subpopulation-driven collateral sensitivity to beta-lactams in an extensively drug-resistant Pseudomonas aeruginosa by Claire Han, Karishma Patel, Haoran Gao, Jacob T. Sanborn, Thomas D. Nguyen, Jack F. Klem, Brian M. Ho, Patrick D. Kenney, Yanan Zhao, Troy D. Wood, Dwayne R. Roach, Liang Chen, Nicholas M. Smith (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13689456.txt.
Description
Claire Han and co-authors show a virus-first trick against a drug-proof lung germ in a 2026 study. The germ, Pseudomonas aeruginosa, haunts hospitals and resists even last-line drugs. Viruses that infect germs, called phages, may reopen doors that drugs lost.
In a hollow-fiber lab model, two phages plus one drug wiped out a lab strain that no single agent could clear. Against a hard clinical strain, phage plus drug pairs beat either alone. The story turns on sub-groups: germs that evolve phage resistance grow leakier coats. A key drug family then slips in more easily. The team calls this collateral sensitivity, a trade the germ cannot dodge both ways at once.
Catalog record
| CREATOR | Claire Han, Karishma Patel, Haoran Gao, Jacob T. Sanborn, Thomas D. Nguyen, Jack F. Klem, Brian M. Ho, Patrick D. Kenney, Yanan Zhao, Troy D. Wood, Dwayne R. Roach, Liang Chen, Nicholas M. Smith |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 44 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |