Comparative transcriptome and proteome analysis of resistant and susceptible Talaromyces marneffei clinical isolates reveals a systemic multitiered defense network against azoles
Zheng Yanqing, Peng Gaoyuan, Pang Xiaofeng, Liang Chaojuan, Luo Xiaolu, Wei Cailing, Qin Jianglong, Zou Jun, Wang Zhiyi, Pan Kaisu, Du Mingwei, Xue Peng, Liao Wanqing, Yu Mei · 2026
Read Comparative transcriptome and proteome analysis of resistant and susceptible Talaromyces marneffei clinical isolates reveals a systemic multitiered defense network against azoles by Zheng Yanqing, Peng Gaoyuan, Pang Xiaofeng, Liang Chaojuan, Luo Xiaolu, Wei Cailing, Qin Jianglong, Zou Jun, Wang Zhiyi, Pan Kaisu, Du Mingwei, Xue Peng, Liao Wanqing, Yu Mei (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13689312.txt.
Description
Zheng Yanqing and thirteen co-authors profile how a killer fungus resists azole drugs in a 2026 paper. The fungus, Talaromyces marneffei, attacks people with weak immunity. Resistant hospital isolates are rising against key drugs. Four resistant and four susceptible isolates were compared deeply.
Gene and protein reads were layered for the comparison. Resistance looks like a built-in, multitiered state. Transport, cell wall work, and detox pathways all shift. Mitochondrial metabolism and stress control join the pattern. A seventeen-gene panel captures the resistant signature. Five panel genes split the groups with statistical force. The panel seeds future mechanism hunts.
Catalog record
| CREATOR | Zheng Yanqing, Peng Gaoyuan, Pang Xiaofeng, Liang Chaojuan, Luo Xiaolu, Wei Cailing, Qin Jianglong, Zou Jun, Wang Zhiyi, Pan Kaisu, Du Mingwei, Xue Peng, Liao Wanqing, Yu Mei |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 47 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |