First characterization of Staphylococcus felis in diabetic foot osteomyelitis: from intracellular persistence to phage treatment
Cynthia N. Abi Najem, Chloé Magnan, Lucile Plumet, Vincent Jean-Pierre, Sophie Schuldiner, Albert Sotto, Jean-Philippe Lavigne, Virginie Molle · 2026
Read First characterization of Staphylococcus felis in diabetic foot osteomyelitis: from intracellular persistence to phage treatment by Cynthia N. Abi Najem, Chloé Magnan, Lucile Plumet, Vincent Jean-Pierre, Sophie Schuldiner, Albert Sotto, Jean-Philippe Lavigne, Virginie Molle (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13689204.txt.
Description
Cynthia Abi Najem and seven co-authors give the first account of a cat-associated bacterium causing bone infection in a diabetic foot. The germ, Staphylococcus felis, lives on cats and had rarely been seen in human illness. Two samples taken from the same patient's bone five months apart let the team watch the germ adapt inside the body. Both samples grew fast, built strong biofilms, and hid inside immune and bone cells, most strongly in bone cells.
In zebrafish tests both samples caused many deaths, proof of virulence. Genome reading showed attack tools, few resistance genes, and small changes between the samples in genes for attack control and iron uptake. A virus that kills bacteria, a phage named SAVM02, blocked the germ in dishes and protected the fish. The later sample differed in virulence and phage response, showing change during the long infection.
Catalog record
| CREATOR | Cynthia N. Abi Najem, Chloé Magnan, Lucile Plumet, Vincent Jean-Pierre, Sophie Schuldiner, Albert Sotto, Jean-Philippe Lavigne, Virginie Molle |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 41 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |