Amphotericin B resistance in Lomentospora prolificans is associated with a soluble cell wall component
Nina T. Grossman, Arturo Casadevall · 2026
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Description
Nina Grossman and Arturo Casadevall probe why a dangerous fungus resists a key antifungal drug in a 2026 study. The fungus infects mainly people with very weak immune systems and shrugs off nearly all drugs. Why the drug amphotericin B fails against it was unknown.
Cells stripped of their walls became far more sensitive to the drug, pointing at the wall as the shield. Material from the fungus soaked up and weakened the drug far more strongly than material from a comparison fungus. Tests traced the blocking factor to a soluble wall component of large size. Two common chemical treatments destroyed its effect. The finding names a new resistance route that future drugs must bypass.
Catalog record
| CREATOR | Nina T. Grossman, Arturo Casadevall |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 30 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |