Spironolactone ameliorates the endothelial dysfunction induced by visceral adipose tissue in obese female mice exposed to early life stress
Nermin Ahmed, Meghan B. Turner, Jacqueline R. Leachman, Anna Seebold, Cole Cincinelli, Carolina Dalmasso, Analia S. Loria · 2026
Read Spironolactone ameliorates the endothelial dysfunction induced by visceral adipose tissue in obese female mice exposed to early life stress by Nermin Ahmed, Meghan B. Turner, Jacqueline R. Leachman, Anna Seebold, Cole Cincinelli, Carolina Dalmasso, Analia S. Loria (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13685720.txt.
Description
Nermin Ahmed and six co-authors published this study in 2026. It explores how early life stress and obesity together strain blood vessels, using female mice. Stress was modeled by separating pups from their mothers and weaning them early, then feeding the adults a high-fat diet.
Fluid taken from the belly fat of stressed obese mice dulled the relaxing response of isolated arteries. Fluid from fat around the vessels themselves did not. A drug that blocks the mineralocorticoid receptor, spironolactone, restored the relaxing response, with the strongest rescue in the stressed group. The pattern points to signals from deep belly fat as the culprit. It also names the blocked receptor as a possible treatment target. The work speaks to the higher heart and metabolic risk women carry after childhood hardship.
Catalog record
| CREATOR | Nermin Ahmed, Meghan B. Turner, Jacqueline R. Leachman, Anna Seebold, Cole Cincinelli, Carolina Dalmasso, Analia S. Loria |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 27 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |