PAK1 Promotes Gluconeogenesis Via the ACSS2/KAT2A/PCK1 Complex to Attenuate Steatotic Liver Ischemia-Reperfusion Injury
Fengqiang Gao, Ye Tao, Zijian Lou, Jinjian Li, Libin Dong, Yuhang Huang, Xiao Tang, Hanzhi Xu, Zhoucheng Wang, Shusen Zheng, Lixing Zhan, Xinyu Yang, Shengjun Xu, Kai Wang, Xiao Xu · 2026
Read PAK1 Promotes Gluconeogenesis Via the ACSS2/KAT2A/PCK1 Complex to Attenuate Steatotic Liver Ischemia-Reperfusion Injury by Fengqiang Gao, Ye Tao, Zijian Lou, Jinjian Li, Libin Dong, Yuhang Huang, Xiao Tang, Hanzhi Xu, Zhoucheng Wang, Shusen Zheng, Lixing Zhan, Xinyu Yang, Shengjun Xu, Kai Wang, Xiao Xu (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13685614.txt.
Description
Fengqiang Gao and co-authors uncover a protective pathway in fatty livers facing the blood-flow cutoff and restoration that transplant surgery imposes. Fatty grafts suffer this injury badly and fail more often, yet donor shortages force their use. In seventy-four transplant recipients, grafts rich in the kinase PAK1 worked better and their recipients survived more. Removing the kinase in models worsened inflammation and cell death; boosting it protected.
The kinase switches on a partner protein, which gathers a third into a complex that tags a metabolic enzyme, raising sugar production by the liver. That shift cut toxic oxygen radicals and improved energy supply. A known drug mimicked the protection in experiments. The authors propose the pathway as a treatment target.
Catalog record
| CREATOR | Fengqiang Gao, Ye Tao, Zijian Lou, Jinjian Li, Libin Dong, Yuhang Huang, Xiao Tang, Hanzhi Xu, Zhoucheng Wang, Shusen Zheng, Lixing Zhan, Xinyu Yang, Shengjun Xu, Kai Wang, Xiao Xu |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 33 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |