Tandem Tau and α-Synuclein Seed Amplification Assays Reveal α-Synuclein Copathology Potentiates Tau Seeding in Alzheimer’s Disease
Claudio Soto, Damian Gorski, Haley Evans, Michelle Pinho, Zaina Rehan, Matthew Perkins, Emile Pinarbasi, Jon Reader, Sami Barmada, Henry Paulson, Sandra Pritzkow · 2026
Read Tandem Tau and α-Synuclein Seed Amplification Assays Reveal α-Synuclein Copathology Potentiates Tau Seeding in Alzheimer’s Disease by Claudio Soto, Damian Gorski, Haley Evans, Michelle Pinho, Zaina Rehan, Matthew Perkins, Emile Pinarbasi, Jon Reader, Sami Barmada, Henry Paulson, Sandra Pritzkow (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13684808.txt.
Description
Claudio Soto and co-authors run two seed tests side by side, for tau and for a second protein. Samples came from the brains and spinal fluid of people who died with Alzheimer's disease or kin conditions. Both proteins can clump in the brain, and they often show up together, yet whether one helps the other seed was not known.
The tau test tracked the true load of tau harm in brain and fluid in step. That load rose with the grade of disease change. The pair of tests lets the team ask, in the same donors, whether the second protein boosts the seeding power of tau, which their title says it does.
Catalog record
| CREATOR | Claudio Soto, Damian Gorski, Haley Evans, Michelle Pinho, Zaina Rehan, Matthew Perkins, Emile Pinarbasi, Jon Reader, Sami Barmada, Henry Paulson, Sandra Pritzkow |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 3 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |