NAE1-Dependent Protein Neddylation Preserves Endothelial Identity and Vascular Integrity
Rachelle Nelson Zoni, Fatema Yeasmin Tanni, Chang Min Lee, Xiao Cheng, Jiyao Zhu, Vijaya Bhaskar Baki, MD Sadikul Islam, Jie Li, Huabo Su, Xinghui Sun · 2026
Read NAE1-Dependent Protein Neddylation Preserves Endothelial Identity and Vascular Integrity by Rachelle Nelson Zoni, Fatema Yeasmin Tanni, Chang Min Lee, Xiao Cheng, Jiyao Zhu, Vijaya Bhaskar Baki, MD Sadikul Islam, Jie Li, Huabo Su, Xinghui Sun (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13684671.txt.
Description
Rachelle Nelson Zoni and co-authors show that a small tag on proteins keeps blood vessel walls sound, in a 2026 study. The tag, a kin of the cell's trash mark, steers much of cell life, yet its role in the vessel wall was unknown.
The team bred mice whose vessel walls could lose the tag's maker on cue. Loss brought swift death, with leaks, clots, swelling, and harm in many organs. Deep reads showed the wall cells lost their core self and lit up paths of swelling and clotting. Two burst-style death paths did much of the harm, and blocking both eased the wounds a lot. Human data tie low tag work to vessel ills as well.
Catalog record
| CREATOR | Rachelle Nelson Zoni, Fatema Yeasmin Tanni, Chang Min Lee, Xiao Cheng, Jiyao Zhu, Vijaya Bhaskar Baki, MD Sadikul Islam, Jie Li, Huabo Su, Xinghui Sun |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 4 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |