Nucleus remodeling activity is conserved amongst diverse SIV Vpr isolates
Zaddock Williford, Emily Leavitt, Nicholas Saladino, Madisyn Johnson, Daniel J Salamango · 2026
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Description
Zaddock Williford, Emily Leavitt, Nicholas Saladino, Madisyn Johnson, and Daniel Salamango asked whether a virus protein keeps its nucleus-bending trick across many strains, in a 2026 study. The protein, Vpr, comes from the monkey cousins of HIV. In HIV it trips the cell's DNA damage alarms, which reshapes the nucleus and helps switch the virus on. Whether that trick is old or new in the family was unclear.
The team tested sixteen Vpr versions from diverse strains. Thirteen set off the damage alarms in infected cells. Those cells also showed more of the marks of open, active genes and stronger action from two switch proteins the virus needs. By mutating one quiet strain, the team found spots the protein needs for the trick. Monkey strains from one branch use a different set of spots, an older path to the same end.
Catalog record
| CREATOR | Zaddock Williford, Emily Leavitt, Nicholas Saladino, Madisyn Johnson, Daniel J Salamango |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 2 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |