A nonlinear inhibition pathway underlying cortical responses to tuned holographic optogenetic perturbations
Ho Yin Chau, Ian Antón Oldenburg, Kenneth D. Miller, Agostina Palmigiano · 2026
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Description
Ho Chau and co-authors explain why stimulating look-alike brain cells together can silence a neighborhood, in a 2026 study. Light-based optogenetics lets scientists poke single cortical cells, but the network's reply often defies linear intuition. Working with mouse visual cortex data, the team built a nonlinear theory of such holographic pokes. A puzzling effect drove the work: clustered cells with similar tuning suppress their surroundings far more than scattered ones.
The model traces that suppression to a feature-tuned inhibitory pathway involving somatostatin-positive interneurons. It predicts those interneurons flare while their parvalbumin cousins quiet down. The spread of the interneuron response sets how strong the effect runs. A predictive theory now guides targeted brain interventions.
Catalog record
| CREATOR | Ho Yin Chau, Ian Antón Oldenburg, Kenneth D. Miller, Agostina Palmigiano |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 1 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |