Triple glutathione depletion-augmented disulfide and lipid peroxide accumulation to potentiate disulfidptosis and ferroptosis
Shulin Du, Moyi Zhang, Hao Zheng, Ran Gao, Jinrong Chen, Rouyu Lin, Jing Li, Mengsi Zhang, Hao Zhang · 2026
Read Triple glutathione depletion-augmented disulfide and lipid peroxide accumulation to potentiate disulfidptosis and ferroptosis by Shulin Du, Moyi Zhang, Hao Zheng, Ran Gao, Jinrong Chen, Rouyu Lin, Jing Li, Mengsi Zhang, Hao Zhang (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13684391.txt.
Description
Shulin Du, Moyi Zhang, Hao Zheng, and a wider team wrote this research paper, published in 2026. It designs a nanoparticle treatment that strips cancer cells of their main antioxidant shield, glutathione, so two forms of cell death can take hold.
Tumor cells lean on glutathione to survive treatments that would otherwise kill them. The team's particle attacks that shield three ways at once. Iron in the particle converts the antioxidant to a spent form. A sulfur linker drains more of it through chemical exchange. Gold dots choke off the supply of a key building block. With the shield gone, harmful compounds pile up inside the cell. That buildup triggers two death pathways, one driven by sulfur compounds and one by iron and fat peroxides. The paper reports the particle's design, traits, and tumor-fighting tests.
Catalog record
| CREATOR | Shulin Du, Moyi Zhang, Hao Zheng, Ran Gao, Jinrong Chen, Rouyu Lin, Jing Li, Mengsi Zhang, Hao Zhang |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 49 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |