Chronic alteration of Ca2+ and hemodynamic signals induced by intracortical microstimulation in the visual cortex of awake mice
Naofumi Suematsu, Alberto L. Vazquez, Takashi DY. Kozai · 2026
Read Chronic alteration of Ca2+ and hemodynamic signals induced by intracortical microstimulation in the visual cortex of awake mice by Naofumi Suematsu, Alberto L. Vazquez, Takashi DY. Kozai (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13684390.txt.
Description
Naofumi Suematsu, Alberto Vazquez, and Takashi Kozai present a 2026 study on what months of brain stimulation do to the cortex. Tiny electrodes planted in the visual cortex can send signals for future prosthetic devices. For such devices to last, doctors must know whether repeated stimulation slowly changes the tissue it touches.
The team implanted electrodes in awake mice and imaged their brains over 12 weeks. They delivered six stimulation rates and also showed light flashes to the other eye. Calcium signals and blood flow signals were tracked week by week. At 25 hertz, calcium responses grew larger and longer over time. High rates and visual input showed fading depression effects instead. Cell bodies and their fine branches followed distinct paths.
Catalog record
| CREATOR | Naofumi Suematsu, Alberto L. Vazquez, Takashi DY. Kozai |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 69 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |