AUT00206, a novel and selective Kv3.1/3.2 channel modulator, restores cognitive dysfunction and negative symptoms in an animal model for schizophrenia symptomatology
Marianne Leger, Daniela Cadinu, Jennifer Fletcher, Agostino Marasco, Giuseppe Alvaro, Daniel Umbricht, Charles Large, Ben Grayson, Joanna C Neill, Michael K Harte · 2026
Read AUT00206, a novel and selective Kv3.1/3.2 channel modulator, restores cognitive dysfunction and negative symptoms in an animal model for schizophrenia symptomatology by Marianne Leger, Daniela Cadinu, Jennifer Fletcher, Agostino Marasco, Giuseppe Alvaro, Daniel Umbricht, Charles Large, Ben Grayson, Joanna C Neill, Michael K Harte (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13683926.txt.
Description
Background:Voltage-gated Kv3.1 and KV3.2 potassium channels are mainly located on parvalbumin (PV) containing interneurons, where they play a key role in synchronising the coordinated firing of pyramidal neurons and regulating cognitive function.Aims:We aim to explore the efficacy of acute treatment with AUT00206 (5,5-dimethyl-3-[2-(7-methylspiro[2H-benzofuran-3,1'-me]-4-yl)oxypyrimidin-5-yl]imidazolidine-2,4-dione), a novel and selective positive modulator of Kv3.1/3.
Catalog record
| CREATOR | Marianne Leger, Daniela Cadinu, Jennifer Fletcher, Agostino Marasco, Giuseppe Alvaro, Daniel Umbricht, Charles Large, Ben Grayson, Joanna C Neill, Michael K Harte |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 36 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |