Personalized Circulating Tumor DNA Analysis for Predicting Outcomes and Tracking Response to Radiotherapy and Pembrolizumab in Localized Sarcomas: Analysis of the SU2C-SARC032 Trial
Ajay Subramanian, Serey CL Nouth, Neda Nemat-Gorgani, Shaghayegh Soudi, Karla V Ballman, Rachel S Heise, Claire Johns, Timothy J Sears, Siyer Roohani, Reinhardt Krcek, Angela M Hong, Kent J Weinhold, Matt van de Rijn, Brian E Brigman, Richard F Riedel, Yvonne M Mowery, David G Kirsch, Everett J Modi · 2026
Read Personalized Circulating Tumor DNA Analysis for Predicting Outcomes and Tracking Response to Radiotherapy and Pembrolizumab in Localized Sarcomas: Analysis of the SU2C-SARC032 Trial by Ajay Subramanian, Serey CL Nouth, Neda Nemat-Gorgani, Shaghayegh Soudi, Karla V Ballman, Rachel S Heise, Claire Johns, Timothy J Sears, Siyer Roohani, Reinhardt Krcek, Angela M Hong, Kent J Weinhold, Matt van de Rijn, Brian E Brigman, Richard F Riedel, Yvonne M Mowery, David G Kirsch, Everett J Modi (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13682727.txt.
Description
Subramanian leads a team testing personal blood DNA tests in patients with localized sarcoma in a 2026 paper. Circulating tumor DNA can forecast outcomes in many cancers. Sarcomas are rare, varied, and carry few mutations, which makes such tests hard.
Samples came from a trial of radiation with or without an immune drug before surgery. Personal assays tracked dozens of each patient's own tumor mutations. The test found tumor DNA in most patients before treatment. Levels at several time points tied strongly to survival and disease-free time. Patients on the immune drug whose levels fell more did better. The authors back trials that act on these readings.
Catalog record
| CREATOR | Ajay Subramanian, Serey CL Nouth, Neda Nemat-Gorgani, Shaghayegh Soudi, Karla V Ballman, Rachel S Heise, Claire Johns, Timothy J Sears, Siyer Roohani, Reinhardt Krcek, Angela M Hong, Kent J Weinhold, Matt van de Rijn, Brian E Brigman, Richard F Riedel, Yvonne M Mowery, David G Kirsch, Everett J Modi |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 43 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |