Guanidine-quaternary ammonium polymer-derived carbon dots differentially modulate bacterial respiration and osteoblast mitochondria to resolve infection and foster osteointegration
Xinxin Bai, Anhui Qin, Zhenguo Wang, Guang Kong, Menghan Zhang, Hongyu Li, Rui Zhao, Yue Yu, Yongfeng Zhang, Qi Liu, Ziqing Zhu, Bing Xia, Shengyou Li, Yiming Hao, Mingze Qin, Dong Lei, Lingli Guo, Meijia Su, Zhuojing Luo, Shaohuang Weng, Teng Ma, Jinghui Huang · 2027
Read Guanidine-quaternary ammonium polymer-derived carbon dots differentially modulate bacterial respiration and osteoblast mitochondria to resolve infection and foster osteointegration by Xinxin Bai, Anhui Qin, Zhenguo Wang, Guang Kong, Menghan Zhang, Hongyu Li, Rui Zhao, Yue Yu, Yongfeng Zhang, Qi Liu, Ziqing Zhu, Bing Xia, Shengyou Li, Yiming Hao, Mingze Qin, Dong Lei, Lingli Guo, Meijia Su, Zhuojing Luo, Shaohuang Weng, Teng Ma, Jinghui Huang (2027) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13682475.txt.
Description
Xinxin Bai and co-authors build carbon dots that kill bacteria while feeding bone cells, in a 2027 paper. Infections around orthopedic implants are among the hardest complications to cure, since antibiotics struggle to clear the implant surface and bone healing stalls. The dots are cooked from a polymer bristling with two bacteria-fighting chemical groups.
The trick exploits how bacteria and bone cells make energy differently. In clean conditions the dots boost the power plants of bone-forming cells, encouraging growth onto the implant. In infected surroundings they punch into bacterial membranes, jam the bacteria's breathing chain, calm host inflammation, and restore the bone cells' power plants. The dots stick stably onto clinical implant materials. A coating that fights germs and grows bone at once could cut the reoperations that infected implants now demand.
Catalog record
| CREATOR | Xinxin Bai, Anhui Qin, Zhenguo Wang, Guang Kong, Menghan Zhang, Hongyu Li, Rui Zhao, Yue Yu, Yongfeng Zhang, Qi Liu, Ziqing Zhu, Bing Xia, Shengyou Li, Yiming Hao, Mingze Qin, Dong Lei, Lingli Guo, Meijia Su, Zhuojing Luo, Shaohuang Weng, Teng Ma, Jinghui Huang |
|---|---|
| YEAR | 2027 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 116 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |