Glioblastoma immune landscape remodeling following treatment with CD70-targeted CAR-T cells
Alexandros Kourtesakis, Dennis Alexander Agardy, Clara Tejido Dierssen, Ling Hai, Dirk Carsten Frieder Hoffmann, Normann Mussnig, Ralph Sinn, Manuel Fischer, Andy Schacht, Michael Breckwoldt, Lukas Bunse, Tim Sauer, Michael Platten, Wolfgang Wick, Tobias Kessler · 2026
Read Glioblastoma immune landscape remodeling following treatment with CD70-targeted CAR-T cells by Alexandros Kourtesakis, Dennis Alexander Agardy, Clara Tejido Dierssen, Ling Hai, Dirk Carsten Frieder Hoffmann, Normann Mussnig, Ralph Sinn, Manuel Fischer, Andy Schacht, Michael Breckwoldt, Lukas Bunse, Tim Sauer, Michael Platten, Wolfgang Wick, Tobias Kessler (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13682394.txt.
Description
Alexandros Kourtesakis and co-authors report a 2026 mouse study of a cell therapy for glioblastoma, a fast and deadly brain cancer. The therapy trains immune cells to hunt tumor cells marked by CD70, a protein on the cancer's surface. Their earlier work showed the cells can wipe out the tumor in mice; now the team asks what the treatment does to the wider immune scene inside the brain.
After treatment, the grafted cells grew, and the mouse's own killer T cells moved in. Groups that hold tumors back, such as regulatory T cells and calming macrophages, shrank. Gene readouts showed stress and shutdown signals fading as the tumor cleared. The authors read this as a shift toward calm watchfulness after the attack.
Catalog record
| CREATOR | Alexandros Kourtesakis, Dennis Alexander Agardy, Clara Tejido Dierssen, Ling Hai, Dirk Carsten Frieder Hoffmann, Normann Mussnig, Ralph Sinn, Manuel Fischer, Andy Schacht, Michael Breckwoldt, Lukas Bunse, Tim Sauer, Michael Platten, Wolfgang Wick, Tobias Kessler |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 65 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |