Key genes and pathways of pulmonary hypertension identified by integrating bulk and single-cell RNA sequencing
Peipei Wu, Jingru Huan, Chengliang Liu, Haiyang Jin, Ran Wang, Yong Wang, Cheng Cao, Binbin Zhang · 2026
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Description
Peipei Wu and seven co-authors hunt for key genes in pulmonary hypertension by joining two kinds of gene data in a study from 2026. In this disease, lung vessel walls thicken and blood pressure in the lungs climbs, but cell-level drivers are still murky. The team merged single-cell data, which maps fourteen lung cell types, with bulk data from whole tissue samples.
Muscle cells of the vessel wall sat at the hub of cell talk. A five-gene signature told patients from controls well. In lab tests, four of those genes rose under low oxygen, and silencing them slowed cell growth. They may serve as markers and drug targets.
Catalog record
| CREATOR | Peipei Wu, Jingru Huan, Chengliang Liu, Haiyang Jin, Ran Wang, Yong Wang, Cheng Cao, Binbin Zhang |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 41 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |