Single-cell RNA sequencing profiles age-related transcriptional landscapes in human hair follicle cells
Qian Zhao, Rui Ma, Kun Huang, Juan Wang, Donglin Zhang, Jingyuan Wang, Xiaofeng Ding, Feiyun Chen, Sijia Zhao, Na Ni, Xiaodie Zhang, Qian Du, Xiaojun Lin, Hua Wan, Jianglin Zhang, Xiaolei Ding, Shuang Yang, Fengping Xu, Yongxian Lai · 2025
Read Single-cell RNA sequencing profiles age-related transcriptional landscapes in human hair follicle cells by Qian Zhao, Rui Ma, Kun Huang, Juan Wang, Donglin Zhang, Jingyuan Wang, Xiaofeng Ding, Feiyun Chen, Sijia Zhao, Na Ni, Xiaodie Zhang, Qian Du, Xiaojun Lin, Hua Wan, Jianglin Zhang, Xiaolei Ding, Shuang Yang, Fengping Xu, Yongxian Lai (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13681660.txt.
Description
Zhao and co-authors map how the human scalp ages, cell by cell. Hair loss and graying are early, visible signs of that aging, driven by worn-out stem cells around the hair root. Using single-cell RNA sequencing and spatial mapping, they profile over 57,000 cells from donors of different ages, with extra volunteers checked by scalp imaging and stains.
They find three subtypes of fast-dividing skin cells and trace how they change over time. In middle-aged scalps, a stress-response switch turns on in skin cells, a pigment gene rises in color cells, and signals between the hair root base and its neighbors fade. The authors note few elderly samples, so late aging stays partly unmapped.
Catalog record
| CREATOR | Qian Zhao, Rui Ma, Kun Huang, Juan Wang, Donglin Zhang, Jingyuan Wang, Xiaofeng Ding, Feiyun Chen, Sijia Zhao, Na Ni, Xiaodie Zhang, Qian Du, Xiaojun Lin, Hua Wan, Jianglin Zhang, Xiaolei Ding, Shuang Yang, Fengping Xu, Yongxian Lai |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 68 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |