TPPU, a soluble epoxide hydrolase inhibitor, mitigates Aβ-induced neurotoxicity via dual modulation of mitochondrial stabilization and JNK suppression
Jingfang Song, Ailan He, Shuyu Li, Qiong Wu · 2026
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Description
Jingfang Song, Ailan He, Shuyu Li, and Qiong Wu published a study in 2026 on a drug that shields rat brain-like cells from amyloid damage. Alzheimer's disease advances as amyloid clumps kill neurons. The team blocked an enzyme whose levels rose in amyloid-treated cells, using its inhibitor TPPU. Survival, death signals, and cell powerhouses were then measured.
The inhibitor cut cell death and restored viability. It normalized a key executioner protein and revived the membrane charge of the powerhouses. Natural fat messengers from the same pathway partly copied the protection. The drug also calmed a stress signaling switch tied to cell death. The authors propose the enzyme as a treatment target.
Catalog record
| CREATOR | Jingfang Song, Ailan He, Shuyu Li, Qiong Wu |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 31 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |