PEX11β controls early neural progenitor fate through regulation of peroxisomal fission and lipid metabolism
C Bodnya, RP Theart, ME Colley, JM Spraggins, V Gama · 2026
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Description
Carolina Bodnya and co-authors ask whether tiny fat handling parts of cells shape early brain growth in a 2026 study. Those parts, called peroxisomes, split to keep their numbers up and to handle fats. The split tools are shared with a second cell part, so it was not clear if the first part acts on its own in brain growth.
The team removed a protein that drives only the first split, in stem cells, then grew them toward nerve cells. Without it, cells had fewer of a key fat type and early nerve groups grew in a changed shape, with larger centers and more young nerve cells. The protein thus has its own role in early brain growth.
Catalog record
| CREATOR | C Bodnya, RP Theart, ME Colley, JM Spraggins, V Gama |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 89 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |