Insulin receptor substrate 2 regulates placental syncytiotrophoblast differentiation at the maternal-fetal interface
Johanna Grinat, María Moya-Navamuel, Paula Blanco-Cueto, Claudia Alemán-Juanes, Nathaly Hernández-Díaz, Maravillas Mellado-López, Amparo Galán, Luke A Noon, Deborah J Burks, Katrien De Clercq, Jorge López-Tello, Vicente Pérez-García · 2026
Read Insulin receptor substrate 2 regulates placental syncytiotrophoblast differentiation at the maternal-fetal interface by Johanna Grinat, María Moya-Navamuel, Paula Blanco-Cueto, Claudia Alemán-Juanes, Nathaly Hernández-Díaz, Maravillas Mellado-López, Amparo Galán, Luke A Noon, Deborah J Burks, Katrien De Clercq, Jorge López-Tello, Vicente Pérez-García (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13681323.txt.
Description
Johanna Grinat and co-authors identify, in a 2026 study, a signaling helper that the placenta needs to build its exchange surface. The labyrinth layer is where mother and fetus trade nutrients and gases. When it fails, the fetus grows poorly.
The helper, called IRS2, sits in the fused cell layers of the mouse labyrinth. Mice lacking it built a disorganized labyrinth with poor cell fusion and fewer fetal blood vessels. Stem cells engineered to lack the gene confirmed the fusion defect in a dish. The work ties one signaling protein to the placenta's core construction job. It may explain some growth restriction cases that currently lack a cause.
Catalog record
| CREATOR | Johanna Grinat, María Moya-Navamuel, Paula Blanco-Cueto, Claudia Alemán-Juanes, Nathaly Hernández-Díaz, Maravillas Mellado-López, Amparo Galán, Luke A Noon, Deborah J Burks, Katrien De Clercq, Jorge López-Tello, Vicente Pérez-García |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 83 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |