Scalable generation of T lymphocytes from human pluripotent stem cells in suspended organoids
Qi Lei, Yudi Miao, Feng Zheng, Ruoqi Cheng, Yating Mo, Weifeng Lai, Zhengyang Zhou, Lejun Lv, Yuanyuan He, Huangfan Xie, Chenyi Dai, Yingfeng Zhang, Zixin Zhao, Mengxin Liu, Lemei Jia, Jun Xu, Cheng Li, Hongkui Deng, Chengyan Wang · 2026
Read Scalable generation of T lymphocytes from human pluripotent stem cells in suspended organoids by Qi Lei, Yudi Miao, Feng Zheng, Ruoqi Cheng, Yating Mo, Weifeng Lai, Zhengyang Zhou, Lejun Lv, Yuanyuan He, Huangfan Xie, Chenyi Dai, Yingfeng Zhang, Zixin Zhao, Mengxin Liu, Lemei Jia, Jun Xu, Cheng Li, Hongkui Deng, Chengyan Wang (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13681316.txt.
Description
Qi Lei and co-authors grow T cells from stem cells in floating organoids in a paper from two thousand twenty-six. T cells are immune cells used in cell therapy, and stem cells could supply them at scale. Making working T cells in suspension culture has been hard.
Their system packs stem-cell-derived blood progenitors with support cells in a gel-based artificial thymus. The organoids made T cells that killed targets in the lab and shrank tumors in animals. A rotating culture then boosted output nearly twenty-fold over still culture. The spun-up cells still secreted signals, multiplied, and killed as expected. The authors say the setup meets both scale and function needs for future therapy.
Catalog record
| CREATOR | Qi Lei, Yudi Miao, Feng Zheng, Ruoqi Cheng, Yating Mo, Weifeng Lai, Zhengyang Zhou, Lejun Lv, Yuanyuan He, Huangfan Xie, Chenyi Dai, Yingfeng Zhang, Zixin Zhao, Mengxin Liu, Lemei Jia, Jun Xu, Cheng Li, Hongkui Deng, Chengyan Wang |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 76 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |