Crossing over: when meiotic recombination impacts linkage-based preimplantation genetic testing for monogenic disorders
Elizabeth J Klein, Mindy S Christianson · 2026
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Description
Klein and Christianson wrote an article, published in 2026, on a pitfall in gene testing of embryos before pregnancy. The testing checks embryos made in the lab for inherited diseases. One route tests the faulty gene itself. Another route tests nearby markers and infers the gene's state from them. That second route is cheaper and sometimes the only option. It rests on the markers and the gene staying together as cells divide.
The catch is a natural swap that can occur when eggs or sperm form. Pieces of matching chromosomes trade places, which can separate a marker from the gene it was tracking. The result can then mislead parents and doctors about an embryo. The authors explain when this risk is highest and how labs can guard against it. Their guidance helps clinics choose and check tests with care.
Catalog record
| CREATOR | Elizabeth J Klein, Mindy S Christianson |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 8 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |