Causal relationship between oral microbiome, circulating inflammatory proteins and lung cancer
Songhe Ping, Dan Li, Jian Sun, Kelong Tao, E. Qin, Renqi Tang, Hongguang Shan, Han Ye, Meng He · 2026
Read Causal relationship between oral microbiome, circulating inflammatory proteins and lung cancer by Songhe Ping, Dan Li, Jian Sun, Kelong Tao, E. Qin, Renqi Tang, Hongguang Shan, Han Ye, Meng He (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13681136.txt.
Description
Songhe Ping and co-authors test whether mouth germs can cause lung cancer, working through blood inflammation proteins, in a 2026 study. Mouth microbes seed the lung's own germ mix, and links to cancer had been seen but not proven causal. The team used Mendelian randomization, a genetics trick that mimics a trial, on large European genome datasets. They covered 43 mouth germ groups, 91 inflammation proteins, and lung cancer subtypes.
Nine germ groups and twenty proteins tied to cancer or its subtypes. One mouth genus raised the risk of squamous cell cancer, while two species guarded against other forms. Certain proteins raised risk, and others, like cystatin D, shielded. One guard germ's shield ran through cystatin D itself, an immune path laid bare. The authors offer the hits as early-warning marks and drug targets.
Catalog record
| CREATOR | Songhe Ping, Dan Li, Jian Sun, Kelong Tao, E. Qin, Renqi Tang, Hongguang Shan, Han Ye, Meng He |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 49 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |