Miro1 mediates skeletal muscle insulin resistance in type 2 diabetes
Elizabeth C Heintz, Wagner S Dantas, Analisa L Taylor, Elizabeth R M Zunica, Kathryn P Belmont, Jackson M Slone, Jacob T Mey, Robbie Beyl, Bolormaa Vandanmagsar, Hailey A Parry, Peter Ajayi, Brian Glancy, Christopher L Axelrod, John P Kirwan · 2026
Read Miro1 mediates skeletal muscle insulin resistance in type 2 diabetes by Elizabeth C Heintz, Wagner S Dantas, Analisa L Taylor, Elizabeth R M Zunica, Kathryn P Belmont, Jackson M Slone, Jacob T Mey, Robbie Beyl, Bolormaa Vandanmagsar, Hailey A Parry, Peter Ajayi, Brian Glancy, Christopher L Axelrod, John P Kirwan (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13680474.txt.
Description
Elizabeth Heintz and co-authors pin a molecular brake on why muscle stops answering insulin in type 2 diabetes, in a 2026 study. The suspect is Miro1, a protein on the surface of mitochondria that manages their movement and shape. In muscle from patients with obesity and diabetes, Miro1 piled up abnormally; mouse models showed the same. The team traced the pile-up to a missed signal: insulin should trigger a partner protein to clear Miro1, and that handshake fails.
Exercise training reversed the build-up in patients while restoring insulin sensitivity. Deleting Miro1 only in mouse muscle improved the muscle's energy capacity and insulin response. The authors cast Miro1 as a regulator worth drugging: clear its excess, and muscle may hear insulin again. Their evidence spans human tissue, a clinical trial, and cell work.
Catalog record
| CREATOR | Elizabeth C Heintz, Wagner S Dantas, Analisa L Taylor, Elizabeth R M Zunica, Kathryn P Belmont, Jackson M Slone, Jacob T Mey, Robbie Beyl, Bolormaa Vandanmagsar, Hailey A Parry, Peter Ajayi, Brian Glancy, Christopher L Axelrod, John P Kirwan |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 93 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |