Fibrinogen Alpha Chain (FGA) Associates With Epithelial–Mesenchymal Transition, Stemness, and the USP–Catenin Complex in Colorectal Cancer
Hao Lin, Weixu Chen, Qing Li · 2026
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Description
Hao Lin, Weixu Chen, and Qing Li wrote this 2026 paper on a clotting protein that tracks with colorectal cancer spread. The protein is fibrinogen alpha chain, part of the molecule that forms blood clots. Cancer growth in the colon is driven in part by cells changing character and gaining stem-like traits.
The team weighed the protein's value as a marker using cancer atlas data, tissue staining, and paired blood samples taken before and after surgery. Its message and protein levels run high in tumor tissue. Cell tests in a colon cancer line used movement and sphere-forming assays to probe what the protein does. Protein pull-down and network analyses hunted for its partners. The trail leads to a complex that steadies catenin, a known driver of cell change. The work casts the clotting protein as both a signal and a possible lever in this cancer.
Catalog record
| CREATOR | Hao Lin, Weixu Chen, Qing Li |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 43 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |