Human Bone Morphogenetic Protein‐3 Mature Ligand Is Larger Than Recorded Indicating Earlier Publications Are Flawed
David E. Phelan, Caitriona Scaife, Emma R. Dorris, John Russell, Madeline Murphy · 2026
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Description
A growth factor used in development and cancer research has been mismeasured for decades, claim David Phelan and co-authors in 2026. The active form of human BMP-3 was long recorded as a 110-amino-acid chain weighing about sixteen kilodaltons.
Their tests show the true mature protein runs 183 amino acids, matching the roughly twenty-five-kilodalton form that human cells actually secrete. The longer chain fits predicted cutting sites, and mass spectrometry confirms its sequence. The finding carries a sting: earlier studies built on the short recorded form used the wrong molecule. The authors say those experiments, and the conclusions drawn from them, need re-examination.
Catalog record
| CREATOR | David E. Phelan, Caitriona Scaife, Emma R. Dorris, John Russell, Madeline Murphy |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 14 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |