Curcumin-loaded alkali-heat-treated titanium modulates macrophage inflammatory responses
Andrew Cedillo, Niloufar Abedi, Sahar Vahabzadeh, Miya Kang · 2026
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Description
Titanium implants can fail when lasting inflammation at the surface blocks bonding with bone. Andrew Cedillo and co-authors loaded a treated titanium surface with curcumin, a natural anti-inflammatory from turmeric, and tested how it leaks out and calms immune cells. Polymer coatings were tried to slow the leak, and release was measured under neutral and acidic conditions.
Uncoated samples released the most curcumin, while one coating cut release and another, added later, stretched it out more gradually. Loading more curcumin raised total release but lowered the share released. Immune cells on the treated surfaces stayed healthier than on polished metal, and curcumin lowered their inflammatory signals at both gene and protein level. The team sees a tunable, calming coat for longer-lived implants.
Catalog record
| CREATOR | Andrew Cedillo, Niloufar Abedi, Sahar Vahabzadeh, Miya Kang |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 56 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |