Gut microbial and metabolomic alterations associated with herpetic trigeminal neuralgia: an exploratory multi-omics study
Mingyue Tian, Yangyang Wang, Cong Li, Jiaming Fan, Qing Chen, Huilian Bu, Xiaochong Fan, Qingying Liu · 2026
Read Gut microbial and metabolomic alterations associated with herpetic trigeminal neuralgia: an exploratory multi-omics study by Mingyue Tian, Yangyang Wang, Cong Li, Jiaming Fan, Qing Chen, Huilian Bu, Xiaochong Fan, Qingying Liu (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13678559.txt.
Description
Mingyue Tian and colleagues ran an exploratory gut study in 2026 on a painful nerve disorder. The disorder follows shingles virus attack on the face nerve. It causes lasting nerve pain with unclear mechanisms. Gut microbes can shape chronic pain through the gut-brain axis. Their role in this disorder was unexplored. The team compared a small patient group with healthy controls. Stool gene sequencing mapped gut microbes and their functions. Chemical profiling covered stool and blood samples. Models hunted for features tied to the disorder.
Patients showed lower gut microbe diversity overall. Helpful acid-making bacteria were depleted. Opportunistic germs were more common instead. Microbe pathways for acid balance and stress defense weakened. Chemical shifts centered on vitamin and signaling pathways. Certain stool chemicals tracked closely with pain scores. The authors frame the results as hypothesis building only. Large, multi-center studies must test these leads, they stress.
Catalog record
| CREATOR | Mingyue Tian, Yangyang Wang, Cong Li, Jiaming Fan, Qing Chen, Huilian Bu, Xiaochong Fan, Qingying Liu |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 63 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |