Association between malocclusion and temporomandibular joint disorders: evidence from a Mendelian randomization study
Zhouqiang Wu, Sen Wang, Chang Liu, Zhiyi Zhao, Yan Feng, Yue Shan, Wen Li, Mengjie Wu · 2026
Read Association between malocclusion and temporomandibular joint disorders: evidence from a Mendelian randomization study by Zhouqiang Wu, Sen Wang, Chang Liu, Zhiyi Zhao, Yan Feng, Yue Shan, Wen Li, Mengjie Wu (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13678557.txt.
Description
Zhouqiang Wu and co-authors test whether a bad bite can cause jaw joint disorders, in a 2026 genetics based study. The two problems often appear together in clinics, but that overlap may be chance rather than cause. Genetic methods can separate cause from mere association.
The team ran the test in both directions using summary data from Finnish and British genome studies. They applied a strict threshold for the many comparisons and checked the strength of their genetic tools. Several methods agreed that certain bite types, including distal, deep, and open bite, may raise the risk of joint disorders. A battery of sensitivity checks probed for bias in those estimates. The authors present the link as potential causation needing clinical care.
Catalog record
| CREATOR | Zhouqiang Wu, Sen Wang, Chang Liu, Zhiyi Zhao, Yan Feng, Yue Shan, Wen Li, Mengjie Wu |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 31 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |