Lysine butyrylation modulates central carbon metabolism and photosynthesis in cyanobacteria
Sihan Li, Mingkun Yang, Jian Lin, Yanyan Chen, Li Yuan, Jiao Zhan, Feng Ge · 2026
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Description
Cyanobacteria run photosynthesis and carbon chemistry in the same cell, and a chemical tag on their proteins may coordinate the two. Li and co-authors map lysine butyrylation, a small molecular tag, across the protein set of a model cyanobacterium for the first time.
They found 132 tag sites on 93 proteins, concentrated in carbon metabolism and light-harvesting machinery. Tag levels across the cell shifted with growth conditions. One tagged enzyme, a builder of the sugar backbone phosphoenolpyruvate, lost activity when the tag was placed at a specific site, position 143, using an engineered genetic code trick. Mutating that site in living cells slowed growth and dimmed photosynthesis under bright light. The authors conclude the tag genuinely steers the cell's core economy.
Catalog record
| CREATOR | Sihan Li, Mingkun Yang, Jian Lin, Yanyan Chen, Li Yuan, Jiao Zhan, Feng Ge |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 62 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |