Development and internal validation of a CatBoost–SHAP-guided nomogram for significant liver fibrosis in children with chronic hepatitis B
Yuanzhen Zhang, Tingting Wu, Yunan Chang, Xiaorong Peng, Kai Zhu, Yijing Liu, Tingting Shang, Tao Qin, Jing Zhu, Jiao Tian, Ruiqiu Zhao, Hongmei Xu · 2026
Read Development and internal validation of a CatBoost–SHAP-guided nomogram for significant liver fibrosis in children with chronic hepatitis B by Yuanzhen Zhang, Tingting Wu, Yunan Chang, Xiaorong Peng, Kai Zhu, Yijing Liu, Tingting Shang, Tao Qin, Jing Zhu, Jiao Tian, Ruiqiu Zhao, Hongmei Xu (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13677468.txt.
Description
Children with chronic hepatitis B can develop serious liver scarring, yet the gold-standard test is a biopsy, too invasive to repeat. Zhang and eleven co-authors build a gentler prediction tool. From 232 children who had biopsies, they trained a learning model to pick the most telling measures. They then built a simple scoring chart, a nomogram, from just three: liver stiffness, a liver enzyme, and platelet count.
The chart identified significant scarring with good accuracy in both the building group and a held-out test group, matching the full learning model. Children classed as high risk improved on some blood measures more slowly and reached viral control later than low-risk children. The authors say the tool could guide care without repeated biopsies. They note it still needs testing in other hospitals before clinical use.
Catalog record
| CREATOR | Yuanzhen Zhang, Tingting Wu, Yunan Chang, Xiaorong Peng, Kai Zhu, Yijing Liu, Tingting Shang, Tao Qin, Jing Zhu, Jiao Tian, Ruiqiu Zhao, Hongmei Xu |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 35 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |