Astrocyte‐Associated ABCA1/APOE Responses Accompany Hippocampal Lipid Remodeling and Ectopic Neuronal Accumulation During Epileptogenesis
Lu Chen, Xiao‐Rui Shi, Jia‐Yi Chen, Ying‐Ting Wang, Le Du, Yang Ni, Jun‐Min Chen, An‐Chen Guo, Qian Wu, Jian‐Ping Wu, Qun Wang · 2026
Read Astrocyte‐Associated ABCA1/APOE Responses Accompany Hippocampal Lipid Remodeling and Ectopic Neuronal Accumulation During Epileptogenesis by Lu Chen, Xiao‐Rui Shi, Jia‐Yi Chen, Ying‐Ting Wang, Le Du, Yang Ni, Jun‐Min Chen, An‐Chen Guo, Qian Wu, Jian‐Ping Wu, Qun Wang (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13677000.txt.
Description
Lu Chen and co-authors study lipid changes linked to astrocytes in the hippocampus as epilepsy takes hold. Published in 2026, the work draws on data from people with temporal lobe epilepsy and from mice whose seizures were set off by chemicals. A transporter called ABCA1 stood out as a lead tied to these cells, with the protein APOE.
Young neurons piled up in the wrong place, near cells marked by ABCA1 and fat droplet markers. A drug that turns on a related receptor raised ABCA1 levels, delayed severe seizures, and was tied to fewer later seizures and less misplaced neuron buildup. Profiling showed wide metabolic and lipid shifts with the drug. Microscopy showed smaller fat droplets in the hurt zone.
Catalog record
| CREATOR | Lu Chen, Xiao‐Rui Shi, Jia‐Yi Chen, Ying‐Ting Wang, Le Du, Yang Ni, Jun‐Min Chen, An‐Chen Guo, Qian Wu, Jian‐Ping Wu, Qun Wang |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 113 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |